The effects of antiinflammatory steroids on the response of the guinea-pig isolated ileum to acetylcholine, histamine, nicotine, 5-hydroxytryptamine and electrical stimulation
Identifieur interne : 003872 ( Main/Exploration ); précédent : 003871; suivant : 003873The effects of antiinflammatory steroids on the response of the guinea-pig isolated ileum to acetylcholine, histamine, nicotine, 5-hydroxytryptamine and electrical stimulation
Auteurs : Jean-Pierre Famaey [Belgique] ; Jeanine Fontaine [Belgique] ; Isabelle Seaman [Belgique] ; Jean Reuse [Belgique]Source :
- Naunyn-Schmiedeberg's Archives of Pharmacology [ 0028-1298 ] ; 1979-11-01.
English descriptors
- KwdEn :
- Teeft :
- Acetylcholine, Agonist, Antiinflammatory, Antiinflammatory drugs, Antiinflammatory steroids, Control responses, Electrical stimulation, Famaey, Fontaine, Gryglewski, High concentrations, Histamine, Ileum, Inhibitory, Inhibitory effect, Inhibitory effects, Nicotine, Pge1, Pgf2, Pharmacol, Prednisolone, Prostaglandin, Smooth muscle, Smooth muscle cells, Statistical analysis, Steroid, Steroidal, Steroidal antiinflammatory drugs, Transmural stimulation, Tromethamine salt, Various agonists.
Abstract
Summary: High concentrations of antiinflammatory steroids (2.5–40 μg/ml) reversibly inhibited the electrically induced contractions of the guinea-pig isolated ileum. At 40 μg/ml they also reversibly inhibited contractions clicited by acetylcholine, histamine, nicotine and 5-hydroxytryptamine. PGE1 (2.5 ng/ml), PGE2 (2.5 ng/ml) and PGF2α (25 ng/ml) antagonized these effects. The inhibition of contractions elicited by direct agonists were less pronounced than those elicited by indirect or partly indirect agonists. The inhibitory effect of steroids may be related to non-specific actions on biological membranes. An overall sensitization of the smooth muscle by PG's may explain their antagonism to inhibition by steroids.
Url:
DOI: 10.1007/BF00501228
Affiliations:
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Pharmacol.</title><idno type="ISSN">0028-1298</idno><idno type="eISSN">1432-1912</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1979-11-01">1979-11-01</date><biblScope unit="volume">309</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="191">191</biblScope><biblScope unit="page" to="195">195</biblScope></imprint><idno type="ISSN">0028-1298</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-1298</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiinflammatory steroids</term><term>Guinea-pig ileum</term><term>Prostaglandins</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acetylcholine</term><term>Agonist</term><term>Antiinflammatory</term><term>Antiinflammatory drugs</term><term>Antiinflammatory steroids</term><term>Control responses</term><term>Electrical stimulation</term><term>Famaey</term><term>Fontaine</term><term>Gryglewski</term><term>High concentrations</term><term>Histamine</term><term>Ileum</term><term>Inhibitory</term><term>Inhibitory effect</term><term>Inhibitory effects</term><term>Nicotine</term><term>Pge1</term><term>Pgf2</term><term>Pharmacol</term><term>Prednisolone</term><term>Prostaglandin</term><term>Smooth muscle</term><term>Smooth muscle cells</term><term>Statistical analysis</term><term>Steroid</term><term>Steroidal</term><term>Steroidal antiinflammatory drugs</term><term>Transmural stimulation</term><term>Tromethamine salt</term><term>Various agonists</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: High concentrations of antiinflammatory steroids (2.5–40 μg/ml) reversibly inhibited the electrically induced contractions of the guinea-pig isolated ileum. At 40 μg/ml they also reversibly inhibited contractions clicited by acetylcholine, histamine, nicotine and 5-hydroxytryptamine. PGE1 (2.5 ng/ml), PGE2 (2.5 ng/ml) and PGF2α (25 ng/ml) antagonized these effects. The inhibition of contractions elicited by direct agonists were less pronounced than those elicited by indirect or partly indirect agonists. The inhibitory effect of steroids may be related to non-specific actions on biological membranes. An overall sensitization of the smooth muscle by PG's may explain their antagonism to inhibition by steroids.</div></front></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li></settlement></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Famaey, Jean Pierre" sort="Famaey, Jean Pierre" uniqKey="Famaey J" first="Jean-Pierre" last="Famaey">Jean-Pierre Famaey</name></region><name sortKey="Fontaine, Jeanine" sort="Fontaine, Jeanine" uniqKey="Fontaine J" first="Jeanine" last="Fontaine">Jeanine Fontaine</name><name sortKey="Reuse, Jean" sort="Reuse, Jean" uniqKey="Reuse J" first="Jean" last="Reuse">Jean Reuse</name><name sortKey="Seaman, Isabelle" sort="Seaman, Isabelle" uniqKey="Seaman I" first="Isabelle" last="Seaman">Isabelle Seaman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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